Radioisotope Development & Production For Industrial & Medical Applications

parsisotope

BLOG

21 September 2014
The new method for Synthesis of Re-188 -Sulphur Colloids

One therapeutic approach to rheumatoid arthritis besides surgical removal is radiation synovectomy using beta-emitting radionuclide to destroy the inflamed synovial tissue. Recently, rhenium radioisotopes have been paid attention more. 188Re sulphur colloid is used for ablation of  knee  inflamed joints.

	The new method for Synthesis of Re-188 -Sulphur Colloids

Purpose:

Our goal is 188Re sulphur colloid synthesis, fulfilling qualification control tests and biodistribution studies of this colloid.

Methods:

After 188Re sulphur colloid synthesis using acidic reduction of sodium thiosulphate in presence of perrhenate, below qualification control testes were implemented:

a) Radiochemical purity: this factor was calculated with TLC (solvent: acetone) and measuring one third TLC paper activity (RF=1/3).

b) Particle size: using DLS Instrument and optical microscope equipped with Motic Images Plus 2.0 software we obtained a good estimation of particle size range.

c) Toxicity studies: with inoculating synthesized sample in microorganism growth medium and successive studies this study was performed.

d) In vitro stability: up to 5 days radiochemical purity and particle size were measured.

In addition, animal studies were implemented with measuring activity of organs of rats been knees injected and killed within 4 days.

Results:

Qualification control tests showed a) radiochemical purity more than 99%, b) more than 95% colloids particles lied in the range of 1-5mm, c) no toxicity and d) colloid was stable to 5 days out of living tissue. In addition, more than 90% of colloid activity was adsorbed in knee joints to four days.

Conclusion:

Because of a) gamma rays emitting, b) suitable half-life and beta energy and c) preventing leakage to other organs by particle size controlling 188Re sulphur colloid is a good alternative as a radiosynovectomy agent for Knee joints.

B.A.Kalantari*, M.R.Davarpanah, R.Nickzad, M.Erfani(Gandomkar), M.Ghannadi Maragheh, M.Mazidi, H.Mirfallah    Nuclear Science and Technology Research Institute, Tehran-Iran